袁晓燕教授

Email: yuanxy@tju.edu.cn

研究所：先进高分子材料研究所

教育背景：

· 1993.9-1997.3，澳门新莆京游戏app大厅应用化学系,工学博士(在职)

· 1985.9-1988.3，澳门新莆京游戏app大厅材料系,高分子材料专业工学硕士

· 1981.9-1985.7，澳门新莆京游戏app大厅应用化学系,高分子化工专业工学学士

工作经历：

· 2021.1-今，澳门新莆京游戏app大厅英才教授

· 2015.3-2015.9，美国Tufts大学，生物医学工程系，高级研究学者(国家留学基金委资助)

· 2003.7-今，澳门新莆京游戏app大厅，澳门新莆京游戏app大厅，教授

· 1998.11-2001.4，香港理工大学，赛马会复康科技中心，副研究员

· 1997.7-2003.6，澳门新莆京游戏app大厅，澳门新莆京游戏app大厅，副教授

· 1990.7-1997.6，澳门新莆京游戏app大厅，材料系，讲师

· 1988-3至1990.6，澳门新莆京游戏app大厅, 材料系, 助教

研究方向

· 研究领域：

生物医用材料：细胞冷冻保护剂、组织再生材料、电纺纤维膜、水凝胶

功能高分子材料：抗冻控冰材料、疏水防冰涂层

聚合物结构与性能：多组分高分子材料、嵌段共聚物结构表征

· 讲授课程：

《生物材料》本科生

《多组分高分子材料》研究生

承担项目

· 国家自然科学基金面上项目，糖功能化聚氨基酸的多级结构调控与冷冻保护细胞和蛋白质的研究，52373152，2024.01-2027.12，主持

· 国家自然科学基金面上项目，生物杂化电纺纤维/水凝胶类血管基质材料及其自适应细胞诱导作用，52073204，2021.01-2024.12，主持

· 国家自然科学基金面上项目，海藻糖氨基酸共聚物的结构调控及其对红细胞的低温冻存保护作用，51773150，2018.01-2021-12，主持

· 天津市科委重点项目，氨基酸聚合物修饰的人工血管材料抗菌抗炎研究，17JCZDJC37500，2017.04-2020-03，主持

· 国家自然科学基金面上项目，多层聚丙交酯共聚物/壳聚糖电纺膜定位负载microRNA的血管再生活性材料，51473118，2015.01-2018-12，主持

· 国家自然科学基金面上项目， POSS-氟丙烯酸酯-聚硅氧烷共聚物微结构调控及低温防冰性能，51273146，2013.01-2016-12，主持

标志性成果：

· Zongze Li, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Synthesis of trehalose-grafted poly(ester amide) with potential ice recrystallization inhibition activity.Polymer,2024, 296, 126819.

· Yueqi Deng, Binlin Chen, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Activation of upper critical solution temperature behaviors of zwitterionic poly(L-methionine-g-poly(sulfobetaine methacrylate)m) with a bottlebrush structure.Macromolecules,2024, 57(1), 191–200.

· Shuhui Gao, Qingjing Niu, Yan Wang, Lixia Ren, Jinghui Chong, Kongying Zhu, Xiaoyan Yuan. A dynamic membrane-active glycopeptide for enhanced protection of human red blood cells against freeze-stress. Adv. Healthc. Mater., 2023, 12(10), 2202516.

· Shan Bai, Jingai Zhang, Yong Gao, Xiaoqi Chen, Kai Wang, and Xiaoyan Yuan. Surface functionalization of electrospun scaffolds by QK-AG73 peptide for enhanced interaction with vascular endothelial cells.Langmuir, 2023, 39(39), 14162–14172.

· Yan Wang, Shuhui Gao, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Integration of trehalose lipids with dissociative trehalose enables cryopreservation of human RBCs.ACS Biomater. Sci. Eng.,2023, 9(1), 498–507.

· Zongze Li, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Sulfonium-containing glycopolypeptides tethering trehalose for protein stabilization.ACS Macro Lett.,2022, 11(11), 1278–1284.

· Xingwen Liu, Shuhui Gao, Lixia Ren, Xiaoyan Yuan. Achieving high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides with synergistic membrane protection of macromolecular protectants.Biomater. Adv.,2022, 141, 213114.

· Qingjing Niu, Shuhui Gao, Kongying Zhu, Jinghui Chong, Lixia Ren, Xiaoyan Yuan. Membrane stabilization versus perturbation by aromatic monoamine-modified γ-PGA for cryopreservation of human RBCs with high intracellular trehalose.J. Mater. Chem. B,2022, 10(31), 6038–6048.

· Shuhui Gao, Kongying Zhu, Qifa Zhang, Qingjing Niu, Jinghui Chong, Lixia Ren, Xiaoyan Yuan. Development of icephilic ACTIVE glycopeptides for cryopreservation of human erythrocytes.Biomacromolecules,2022, 23(2), 530–542.

· Qifa Zhang, Bo Liu, Jinghui Chong, Lixia Ren, Yunhui Zhao, Xiaoyan Yuan. Combination of hydrophobically modified γ-poly(glutamic acid) and trehalose achieving high cryosurvival of RBCs.Sci. China Technol. Sc.,2021, 64(4), 806–816.

· Bo Liu, Lingyue Zhang, Qifa Zhang, Shuhui Gao, Yunhui Zhao, Lixia Ren, Wenxiong Shi, Xiaoyan Yuan. Membrane stabilization of poly(ethylene glycol)-b-polypeptide-g-trehalose assists cryopreservation of red blood cells.ACS Appl. Bio Mater.,2020, 3(5), 3294–3303.

· Meiling Wen, Dengke Zhi, Lina Wang, Ce Cui, Ziqi Huang, Yunhui Zhao, Kai Wang, Deling Kong, Xiaoyan Yuan. Local delivery of dual microRNAs in trilayered electrospun grafts for vascular regeneration.ACS Appl. Mater. Interfaces,2020, 12(6), 6863–6875.

· Bo Liu, Qifa Zhang, Fang Zhou, Lixia Ren, Yunhui Zhao, Xiaoyan Yuan. Enhancing membrane-disruptive activity via hydrophobic phenylalanine and lysine tethered to poly(aspartic acid).ACS Appl. Mater. Interfaces,2019, 11(16), 14538–14547.